Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion

Author:

Carden Marcus A.12,Fay Meredith E.12,Lu Xinran3,Mannino Robert G.12,Sakurai Yumiko12,Ciciliano Jordan C.14,Hansen Caroline E.15,Chonat Satheesh1,Joiner Clinton H.1,Wood David K.3,Lam Wilbur A.12

Affiliation:

1. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Aflac Cancer & Blood Disorders Center, Emory University School of Medicine, Atlanta, GA;

2. The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA;

3. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN;

4. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, and

5. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA

Abstract

Key Points Intravenous fluids are used when treating VOE, but guidelines are lacking, and how IVF tonicity affects sickle red cell biomechanics is unknown. Modifying extracellular fluid tonicity alters deformability, adhesivity, and occlusion risk for sRBCs in microfluidic vascular models.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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