Rapid discrimination of the phenotypic variants of von Willebrand disease

Author:

Roberts Jonathan C.12ORCID,Morateck Patti A.1,Christopherson Pamela A.1,Yan Ke1,Hoffmann Raymond G.1,Gill Joan Cox1,Montgomery Robert R.1,

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin and Medical College of Wisconsin, Milwaukee, WI; and

2. Bleeding & Clotting Disorders Institute, Peoria, IL

Abstract

Key Points A novel ELISA-based VWF multiplex activity assay assigns VWD phenotype among a cohort of type 1 and 2 VWD with an overall accuracy of >88%. This assay shows correlation with traditional quantitative clinical VWF assays and may provide a rapid diagnostic method for variant VWD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference54 articles.

1. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).;Nichols;Haemophilia,2008

2. Epidemiological investigation of the prevalence of von Willebrand’s disease.;Rodeghiero;Blood,1987

3. Prevalence of von Willebrand disease in children: a multiethnic study.;Werner;J Pediatr,1993

4. Relative value of diagnostic studies for von Willebrand disease.;Werner;J Pediatr,1992

5. Inconsistency of association between type 1 von Willebrand disease phenotype and genotype in families identified in an epidemiological investigation.;Castaman;Thromb Haemost,1999

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