Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas-Reference-Cited by-同舟云学术

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Published:2013-04-11 Issue:15 Volume:121 Page:2964-2974
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shortt Jake¹²,Martin Benjamin P.¹²,Newbold Andrea¹²,Hannan Katherine M.²³,Devlin Jennifer R.²³,Baker Adele J.¹²,Ralli Rachael¹²,Cullinane Carleen²⁴,Schmitt Clemens A.⁵⁶,Reimann Maurice⁵,Hall Michael N.⁷,Wall Meaghan²³,Hannan Ross D.²³,Pearson Richard B.²³,McArthur Grant A.²³⁴,Johnstone Ricky W.¹²

Affiliation:

1. Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Australia;

2. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia;

3. Oncogenic Signalling and Growth Control Program and

4. Translational Research Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Australia;

5. Charité-Universitätsmedizin Berlin/Molekulares Krebsforschungszentrum, Berlin, Germany;

6. Max Delbrück Center for Molecular Medicine, Berlin, Germany; and

7. Biozentrum, University of Basel, Basel, Switzerland

Abstract

Key PointsMYC-driven lymphomas demonstrate activation of mTORC1 and an endogenous DNA damage response. BEZ235 inhibits PI3K-related DNA damage response kinases and mTORC1, inducing p53-independent upregulation of proapoptotic BMF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/2964/1365855/2964.pdf

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4. Advances in the understanding of MYC-induced lymphomagenesis.;Klapproth;Br J Haematol,2010

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