CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines-Reference-Cited by-同舟云学术

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

Published:2013-04-04 Issue:14 Volume:121 Page:2647-2658
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pesenacker Anne M.¹,Bending David¹,Ursu Simona¹,Wu Qiong¹,Nistala Kiran²,Wedderburn Lucy R.¹

Affiliation:

1. Rheumatology Unit, UCL Institute of Child Health, University College London, London, United Kingdom; and

2. Rheumatology Unit, Department of Medicine, University College London, London, United Kingdom

Abstract

Key Points CD161 defines proinflammatory FoxP3+ cells that have classic Treg signatures, yet share effector T-cell properties. CD161+ Treg proinflammatory phenotype is stable upon Treg expansion and thus should be considered in therapeutic strategies using Treg.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/14/2647/1365599/2647.pdf

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