A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation-Reference-Cited by-同舟云学术

A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation

Published:2013-02-14 Issue:7 Volume:121 Page:1145-1156
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sehrawat Sharvan¹,Koenig Paul-Albert¹,Kirak Oktay²,Schlieker Christian³,Fankhauser Manuel¹,Ploegh Hidde L.¹

Affiliation:

1. Whitehead Institute for Biomedical Research, Cambridge, MA;

2. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA; and

3. Molecular Biophysics and Biochemistry Department, Yale University, New Haven, CT

Abstract

Key Points Antigen cross-presentation is regulated by the activity of deubiquitylase YOD1 that influences the control of viral infections. The enhanced cross-presentation depends on the proteasomal activity and the acidification status of APCs but is independent of functional TAP1.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/7/1145/1368581/zh800713001145.pdf

Reference45 articles.

1. Cross-presentation: underlying mechanisms and role in immune surveillance.;Rock;Immunol Rev,2005

2. The known unknowns of antigen processing and presentation.;Vyas;Nat Rev Immunol,2008

3. Inhibition of dendritic cell maturation by herpes simplex virus.;Salio;Eur J Immunol,1999

4. Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells.;Servet-Delprat;J Immunol,2000

5. Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion.;Engelmayer;J Immunol,1999

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