A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure-Reference-Cited by-同舟云学术

A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure

Published:2013-10-10 Issue:15 Volume:122 Page:2562-2571
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aronovich Anna¹,Nur Yaniv¹,Shezen Elias¹,Rosen Chava¹,Zlotnikov Klionsky Yael¹,Milman Irit¹,Yarimi Liran¹,Hagin David¹,Rechavi Gidi²,Martinowitz Uriel³,Nagasawa Takashi⁴⁵,Frenette Paul S.⁶,Tchorsh-Yutsis Dalit¹,Reisner Yair¹

Affiliation:

1. Immunology Department, Weizmann Institute of Science, Rehovot, Israel;

2. Cancer Research Center, and

3. The Israel National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel;

4. Department of Immunobiology and Hematology, Institute for Frontier, Medical Sciences, Kyoto University, Kyoto, Japan;

5. Japan Science and Technology Agency, Core Research for Evolutional Science and, Technology, Tokyo, Japan; and

6. Institute for Stem Cell and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY

Abstract

Key PointsThe coagulation cascade via the factor VIII/thrombin/PAR1 axis regulates HSC maintenance. The coagulation cascade via factor VIII/thrombin/PAR1 axis regulates a reciprocal interplay between HSCs and the dynamic bone structure.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/15/2562/1368835/2562.pdf

Reference41 articles.

1. Size control in animal development.;Conlon;Cell,1999

2. Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation.;Aronovich;Proc Natl Acad Sci USA,2006

3. Can spleen transplantation induce tolerance? A review of the literature.;Dor;Transpl Int,2003

4. Enhancement of pig embryonic implants in factor VIII KO mice: a novel role for the coagulation cascade in organ size control.;Aronovich;PLoS ONE,2009

5. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver.;Stanger;Nature,2007

Cited by 36 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Specific serum biomarkers to assess the bone health in a group of hemophilia A carriers: Data from the CAR.BONE study;Thrombosis Research;2024-01

2. Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis;Thrombosis and Haemostasis;2023-03-13

3. CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII;Blood Advances;2023-03-01

4. Pathogenesis and treatment of osteoporosis in patients with hemophilia;Archives of Osteoporosis;2023-01-04

5. Osteoporosis management and falls prevention in patients with haemophilia: Review of haemophilia guidelines;Haemophilia;2022-03-15