Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells-Reference-Cited by-同舟云学术

Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells

Published:2013-06-06 Issue:23 Volume:121 Page:4708-4717
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zwick Carsten¹,Fadle Natalie¹,Regitz Evi¹,Kemele Maria¹,Stilgenbauer Stephan²,Bühler Andreas²,Pfreundschuh Michael¹,Preuss Klaus-Dieter¹

Affiliation:

1. Jose-Carreras Center for Immuno- and Gene Therapy, Department Internal Medicine I, Saarland University Medical School, Homburg (Saar), Germany; and

2. Department Internal Medicine III, Ulm University, Ulm, Germany

Abstract

Key Points Autoantigens bind to and induce proliferation of CLL cells, supporting chronic antigenic stimulation as an important pathomechanism in CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/23/4708/1366070/4708.pdf

Reference44 articles.

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3. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.;Fais;J Clin Invest,1998

4. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.;Damle;Blood,1999

5. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.;Hamblin;Blood,1999

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