Heparin rescues factor V Leiden–associated placental failure independent of anticoagulation in a murine high-risk pregnancy model-Reference-Cited by-同舟云学术

Heparin rescues factor V Leiden–associated placental failure independent of anticoagulation in a murine high-risk pregnancy model

Published:2013-03-14 Issue:11 Volume:121 Page:2127-2134
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

An Jianzhong¹,Waitara Magarya S.¹,Bordas Michelle¹,Arumugam Vidhyalakshmi¹,Hoffmann Raymond G.²,Petrich Brian G.³,Sinha Uma⁴,North Paula E.¹⁵⁶,Sood Rashmi¹⁵

Affiliation:

1. Division of Pediatric Pathology, Department of Pathology, and

2. Quantitative Health Sciences, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;

3. Department of Medicine, University of California, San Diego, CA;

4. Portola Pharmaceuticals Inc, South San Francisco, CA; and

5. Children’s Research Institute, and

6. Children’s Hospital of Wisconsin, Children’s Hospital and Health System, Milwaukee, WI

Abstract

Key Points Heparin may have beneficial effects on placental health beyond anticoagulation. Thrombin receptor activation on maternal platelets is implicated in placental developmental failure independent of thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/11/2127/1364372/2127.pdf

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5. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study.;Brenner;J Thromb Haemost,2005

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