Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans-Reference-Cited by-同舟云学术

Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans

Published:2013-04-11 Issue:15 Volume:121 Page:2975-2987
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Görgün Güllü Topal¹,Whitehill Gregory¹²,Anderson Jennifer L.¹³,Hideshima Teru¹,Maguire Craig¹,Laubach Jacob¹,Raje Noopur⁴,Munshi Nikhil C.¹⁵,Richardson Paul G.¹,Anderson Kenneth C.¹

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Haverford College, Haverford, PA;

3. Massachusetts College of Pharmacy and Health Sciences, Boston, MA;

4. Massachusetts General Hospital, Boston, MA; and

5. VA Boston Healthcare System, Boston, MA

Abstract

Key Points MDSCs are increased in patients with MM and have bidirectional interaction with tumors in the MM microenvironment. MM-MDSCs promote MM growth and induce immune suppression; conversely, MM cells induce MDSC development.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/2975/1366170/2975.pdf

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