Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation

Author:

Blyth Emily12345,Clancy Leighton123,Simms Renee1,Ma Chun K. K.1,Burgess Jane1,Deo Shivashni1,Byth Karen56,Dubosq Ming-Celine2,Shaw Peter J.57,Micklethwaite Kenneth P.12345,Gottlieb David J.12345

Affiliation:

1. Westmead Millennium Institute, University of Sydney, Sydney, Australia;

2. Department of Haematology,

3. Sydney Cellular Therapies Laboratory, and

4. Blood and Marrow Transplant Service, Westmead Hospital, Sydney, Australia;

5. Sydney Medical School, University of Sydney, Sydney, Australia;

6. Department of Medicine, Westmead Hospital, Sydney, Australia; and

7. Oncology Unit, Children's Hospital at Westmead, Sydney, Australia

Abstract

Key Points Infusion of CMV-specific T cells early posttransplant does not increase acute or chronic graft-versus-host disease. CMV-specific T cells early posttransplant reduce the need for pharmacotherapy without increased rates of CMV-related organ damage.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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