AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway-Reference-Cited by-同舟云学术

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway

Published:2013-06-13 Issue:24 Volume:121 Page:4906-4916
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Yiyun¹²,Wang Jianfeng²³,Wheat Justin³,Chen Xi³,Jin Shan¹²,Sadrzadeh Hossein⁴,Fathi Amir T.²⁴,Peterson Randall T.¹²⁵,Kung Andrew L.⁵⁶,Sweetser David A.²³,Yeh Jing-Ruey Joanna¹²

Affiliation:

1. Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA;

2. Department of Medicine, Harvard Medical School, Boston, MA;

3. Department of Pediatrics, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Boston, MA;

4. Massachusetts General Hospital Cancer Center, Boston, MA;

5. The Broad Institute, Cambridge, MA; and

6. Department of Pediatrics, Columbia University Medical Center, New York, NY

Abstract

Key Points AE induces hematopoietic self-renewal through a COX/prostaglandin E2/β-catenin signaling pathway. Clinically available COX inhibitors may target AML stem cells and suppress AML of various karyotypes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/24/4906/1366595/4906.pdf

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4. Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.;Mulloy;Blood,2003

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