Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction-Reference-Cited by-同舟云学术

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

Published:2013-05-02 Issue:18 Volume:121 Page:3619-3630
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rosborough Brian R.¹,Raïch-Regué Dàlia¹,Matta Benjamin M.¹,Lee Keunwook²,Gan Boyi³,DePinho Ronald A.⁴,Hackstein Holger⁵,Boothby Mark²⁶,Turnquist Hēth R.¹⁷,Thomson Angus W.¹⁷

Affiliation:

1. Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA;

2. Department of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, TN;

3. Department of Experimental Radiation Oncology and

4. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX;

5. Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen and German Center for Lung Research, Giessen, Germany;

6. Department of Medicine (Rheumatology), Vanderbilt University School of Medicine, Nashville, TN; and

7. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Abstract

Key Points RAPA-resistant mTOR negatively regulates DC B7-H1 expression through signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3. Adenosine triphosphate–competitive mTOR inhibition promotes B7-H1–dependent DC induction of Tregs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3619/1363512/3619.pdf

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