Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia

Author:

Ishihara Makoto1,Araya Natsumi2,Sato Tomoo2,Tatsuguchi Ayako1,Saichi Naomi1,Utsunomiya Atae3,Nakamura Yusuke4,Nakagawa Hidewaki1,Yamano Yoshihisa2,Ueda Koji1

Affiliation:

1. Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Tokyo, Japan;

2. Department of Molecular Medical Science, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan;

3. Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan; and

4. Section of Hematology/Oncology, Department of Medicine Faculty, The University of Chicago, Chicago, IL

Abstract

Key Points Proteome-wide analysis of HTLV-1–infected T cells identified 17 biomarker proteins for the diagnosis of ATL or HAM/TSP patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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