Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation

Author:

Cieri Nicoletta123,Oliveira Giacomo13,Greco Raffaella23,Forcato Mattia4,Taccioli Cristian4,Cianciotti Beatrice1,Valtolina Veronica15,Noviello Maddalena1,Vago Luca26,Bondanza Attilio123,Lunghi Francesca2,Marktel Sarah2,Bellio Laura7,Bordignon Claudio35,Bicciato Silvio4,Peccatori Jacopo2,Ciceri Fabio267,Bonini Chiara1

Affiliation:

1. Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Program in Immunology and Bio-immunotherapy of Cancer and

2. Hematology and Bone Marrow Transplantation Unit, Department of Oncology, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy;

3. University Vita-Salute San Raffaele, Milan, Italy;

4. Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy;

5. Molmed S.p.A., Milan, Italy

6. Unit of Molecular and Functional Immunogenetics and

7. Immunohematology and Transfusion Medicine Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy; and

Abstract

Key Points TSCM lymphocytes are preferentially generated from naive precursors in vivo early after haploidentical HSCT. TSCM represent relevant novel players in the diversification of immunological memory after haploidentical HSCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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