A practical approach to the diagnosis of systemic amyloidoses

Author:

Fernández de Larrea Carlos12,Verga Laura3,Morbini Patrizia3,Klersy Catherine4,Lavatelli Francesca1,Foli Andrea1,Obici Laura1,Milani Paolo1,Capello Gian Luca3,Paulli Marco3,Palladini Giovanni1,Merlini Giampaolo1

Affiliation:

1. Amyloidosis Research and Treatment Center, Department of Molecular Medicine, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and University of Pavia, Pavia, Italy;

2. Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic and Institut d’Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain;

3. Pathology Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and University of Pavia, Pavia, Italy; and

4. Scientific Direction, Biometry and Statistics, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy

Abstract

Key Points The first wide, prospective report on the role of IEM in the differential diagnosis of systemic amyloidosis. IEM allows for the correct characterization of the amyloid protein in virtually all cases and represents a viable alternative to mass spectrometry.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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