Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology

Author:

Hovorkova Lenka12,Zaliova Marketa123,Venn Nicola C.4,Bleckmann Kirsten5,Trkova Marie6,Potuckova Eliska12,Vaskova Martina12,Linhartova Jana7,Machova Polakova Katerina7,Fronkova Eva12,Muskovic Walter4,Giles Jodie E.4,Shaw Peter J.8,Cario Gunnar5,Sutton Rosemary49,Stary Jan23,Trka Jan123,Zuna Jan123

Affiliation:

1. Childhood Leukemia Investigation Prague (CLIP) and

2. Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic;

3. University Hospital Motol, Prague, Czech Republic;

4. Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia;

5. Department of Pediatrics, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany;

6. Gennet, Center for Fetal Medicine and Reproductive Genetics, Prague, Czech Republic;

7. Institute of Hematology and Blood Transfusion, Prague, Czech Republic;

8. Blood and Marrow Transplant Services, Children’s Hospital at Westmead, Sydney, NSW, Australia; and

9. School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW, Australia

Abstract

Key Points Combination of Ig/TCR and BCR-ABL1 genomic approach for MRD monitoring in childhood ALL reveals patients with CML-like disease. Monitoring ALL using BCR-ABL1 genomic breakpoint is feasible and enables the most specific and sensitive MRD quantification.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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