p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma-Reference-Cited by-同舟云学术

p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma

Published:2017-03-09 Issue:10 Volume:129 Page:1308-1319
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hideshima Teru¹,Cottini Francesca¹,Nozawa Yoshihisa²,Seo Hyuk-Soo³⁴,Ohguchi Hiroto¹,Samur Mehmet K.⁵⁶,Cirstea Diana¹,Mimura Naoya¹,Iwasawa Yoshikazu²,Richardson Paul G.¹,Munshi Nikhil C.¹,Chauhan Dharminder¹,Massefski Walter³,Utsugi Teruhiro²,Dhe-Paganon Sirano³⁴,Anderson Kenneth C.¹

Affiliation:

1. Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Discovery and Preclinical Research Division, TAIHO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan;

3. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA;

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA;

5. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; and

6. Harvard School of Public Health, Boston, MA

Abstract

Key Points TP53RK confers poor prognosis in MM patients. TP53RK knockdown or inhibition by IMiDs triggers MM cell apoptosis, validating TP53RK as a novel therapeutic target in MM.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/10/1308/1399295/blood738500.pdf

Reference50 articles.

1. The rapid evolution of novel therapies in multiple myeloma;Anderson;J Natl Compr Canc Netw,2016

2. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy;Lohr;Cancer Cell,2014

3. Heterogeneity of genomic evolution and mutational profiles in multiple myeloma;Bolli;Nat Commun,2014

4. Synthetic lethal approaches exploiting DNA damage in aggressive myeloma;Cottini;Cancer Discov,2015

5. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes;Abe;J Biol Chem,2001

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