Ponatinib efficacy and safety in Philadelphia chromosome–positive leukemia: final 5-year results of the phase 2 PACE trial

Author:

Cortes Jorge E.1,Kim Dong-Wook2,Pinilla-Ibarz Javier3,le Coutre Philipp D.4,Paquette Ronald5,Chuah Charles6,Nicolini Franck E.7,Apperley Jane F.8,Khoury H. Jean9,Talpaz Moshe10,DeAngelo Daniel J.11,Abruzzese Elisabetta12,Rea Delphine13,Baccarani Michele14,Müller Martin C.15,Gambacorti-Passerini Carlo16,Lustgarten Stephanie17,Rivera Victor M.17,Haluska Frank G.17,Guilhot François1819,Deininger Michael W.20,Hochhaus Andreas21,Hughes Timothy P.22,Shah Neil P.23,Kantarjian Hagop M.1

Affiliation:

1. The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Seoul St. Mary’s Hospital, Leukemia Research Institute, The Catholic University of Korea, Seoul, South Korea;

3. H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL;

4. Charité, Universitätsmedizin Berlin, Berlin, Germany;

5. Cedars-Sinai Medical Center, Los Angeles, CA;

6. Singapore General Hospital, Duke–National University of Singapore (NUS) Medical School, Singapore;

7. Centre Hospitalier Lyon-Sud, Pierre-Bénite, Lyon, France;

8. Centre for Haematology, Imperial College, London, United Kingdom;

9. Winship Cancer Institute of Emory University, Atlanta, GA;

10. Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI;

11. Dana-Farber Cancer Institute, Boston, MA;

12. S. Eugenio Hospital, Tor Vergata University, Rome, Italy;

13. Service d’Hématologie Adulte et Centre d’Investigation Clinique, Hôpital Saint Louis, Paris, France;

14. Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy;

15. III. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;

16. University of Milano-Bicocca/San Gerardo Hospital, Monza, Italy;

17. ARIAD Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited;

18. Centre d’Investigation Clinique (CIC) 1402, INSERM, Poitiers, France;

19. Centre Hospitalier Universitaire de Poitiers, Poitiers, France;

20. Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;

21. Hematology/Oncology, Jena University Hospital, Jena, Germany;

22. University of Adelaide/South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia; and

23. Department of Medicine, Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA

Abstract

Key Points Ponatinib continued to provide deep, durable responses in heavily pretreated patients with CP-CML. Tolerability was acceptable in this heavily pretreated population with 5 years of follow-up.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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