Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia-Reference-Cited by-同舟云学术

Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia

Published:2017-03-30 Issue:13 Volume:129 Page:1855-1864
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cao Muhua¹²,Li Tao¹²,He Zhangxiu¹,Wang Lixiu³,Yang Xiaoyan¹,Kou Yan¹,Zou Lili⁴,Dong Xue¹,Novakovic Valerie A.⁵,Bi Yayan³,Kou Junjie⁴,Yu Bo²,Fang Shaohong²,Wang Jinghua⁶,Zhou Jin¹,Shi Jialan¹⁷

Affiliation:

1. Department of Hematology, The First Hospital, Harbin Medical University, Harbin, China;

2. The Key Laboratory of Myocardial Ischemia, Ministry of Education, Heilongjiang Province, Harbin, China;

3. Department of Cardiology, The First Hospital, and

4. Department of Cardiology, The Second Hospital, Harbin Medical University, Harbin, China;

5. Department of Research, VA Boston Healthcare System, Boston, MA;

6. Department of Hematology, The Second Hospital, Harbin Medical University, Harbin, China; and

7. Department of Surgery, Brigham and Women’s Hospital, VA Boston Healthcare System and Harvard Medical School, Boston, MA

Abstract

Key Points ATRA promotes ETosis leading to procoagulant promyelocytic extracellular chromatin. Extracellular chromatin fosters excess thrombin production and fibrin deposition, increases plasmin, and causes endothelium damage.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/13/1855/1399708/blood739334.pdf

Reference46 articles.

1. Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid;Park;Blood,2011

2. Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry;Lehmann;Leukemia,2011

3. Treatment advances have not improved the early death rate in acute promyelocytic leukemia;McClellan;Haematologica,2012

4. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure;de Thé;Nat Rev Cancer,2010

5. Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome;Sanz;Blood,2010

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hemorrhage in acute promyelocytic leukemia—fibrinolysis in focus;Research and Practice in Thrombosis and Haemostasis;2024-07

2. Targeting neutrophil extracellular traps: A novel strategy in hematologic malignancies;Biomedicine & Pharmacotherapy;2024-04

3. Impaired fibrinolysis and increased clot strength are potential risk factors for thrombosis in lymphoma;Blood Advances;2023-11-20

4. Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study;Signal Transduction and Targeted Therapy;2023-09-27

5. Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers;CNS Neuroscience & Therapeutics;2023-06-27