Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft

Author:

Schroeder Mark A.1,Rettig Michael P.1,Lopez Sandra1,Christ Stephanie1,Fiala Mark1,Eades William1,Mir Fazia A.2,Shao Jin1,McFarland Kyle1,Trinkaus Kathryn3,Shannon William3,Deych Elena3,Yu Jinsheng4,Vij Ravi1,Stockerl-Goldstein Keith1,Cashen Amanda F.1,Uy Geoffrey L.1,Abboud Camille N.1,Westervelt Peter1,DiPersio John F.1

Affiliation:

1. Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO;

2. Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO; and

3. Division of Biostatistics and

4. Department of Genetics, Washington University School of Medicine, St. Louis, MO

Abstract

Key Points Plerixafor is a safe, effective, rapid mobilizing agent when administered intravenously. Lower rates of GVHD and CMV viremia with plerixafor-mobilized grafts may be related to a unique cellular composition of the graft.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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