Multiple myeloma cells’ capacity to decompose H2O2 determines lenalidomide sensitivity-Reference-Cited by-同舟云学术

Multiple myeloma cells’ capacity to decompose H2O2 determines lenalidomide sensitivity

Published:2017-02-23 Issue:8 Volume:129 Page:991-1007
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sebastian Sinto¹,Zhu Yuan X.¹,Braggio Esteban¹,Shi Chang-Xin¹,Panchabhai Sonali C.¹,Van Wier Scott A.¹,Ahmann Greg J.¹,Chesi Marta¹,Bergsagel P. Leif¹,Stewart A. Keith¹,Fonseca Rafael¹

Affiliation:

1. Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ

Abstract

Key Points IMiDs inhibit TrxR-mediated intracellular decomposition of H2O2 and caused oxidative stress in MM cells. MM cells with lower antioxidative capacity were more vulnerable to lenalidomide-induced H2O2 accumulation and its associated cytotoxicity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/8/991/1465540/blood738872.pdf

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