Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells-Reference-Cited by-同舟云学术

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells

Published:2017-06-15 Issue:24 Volume:129 Page:3184-3195
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rogers Geoffrey L.¹,Shirley Jamie L.¹,Zolotukhin Irene¹,Kumar Sandeep R. P.¹,Sherman Alexandra¹,Perrin George Q.¹,Hoffman Brad E.¹,Srivastava Arun¹,Basner-Tschakarjan Etiena²,Wallet Mark A.³,Terhorst Cox⁴,Biswas Moanaro¹,Herzog Roland W.¹

Affiliation:

1. Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL;

2. Center of Molecular and Cellular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL; and

4. Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract

Key Points Crosspriming of AAV capsid-specific CD8+ T cells requires cooperation between distinct subsets of DCs. Innate immune sensing of the viral DNA genome induces cross-presentation of viral capsid in trans.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/24/3184/1401310/blood751040.pdf

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