Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils-Reference-Cited by-全球学者库

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils

Published:2017-07-20 Issue:3 Volume:130 Page:328-339
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Khan Zakir¹²,Shen Xiao Z.³,Bernstein Ellen A.¹²,Giani Jorge F.¹²,Eriguchi Masahiro¹²,Zhao Tuantuan V.¹²,Gonzalez-Villalobos Romer A.¹²⁴,Fuchs Sebastien⁵,Liu George Y.¹⁶⁷,Bernstein Kenneth E.¹²

Affiliation:

1. Department of Biomedical Sciences and

2. Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA;

3. Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China;

4. Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA;

5. Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA; and

6. Division of Pediatric Infectious Diseases and

7. Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA

Abstract

Key Points ACE plays an important physiological role in neutrophil antibacterial activity. ACE upregulation in mice neutrophils strongly enhances bactericidal activity via increased reduced NAD phosphate oxidase production of ROS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/3/328/1405112/blood752006.pdf

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4. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology;Bedard;Physiol Rev,2007

5. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation;Remijsen;Cell Res,2011

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