Extracellular vesicle–mediated transfer of constitutively active MyD88L265P engages MyD88wt and activates signaling-Reference-Cited by-同舟云学术

Extracellular vesicle–mediated transfer of constitutively active MyD88L265P engages MyD88wt and activates signaling

Published:2018-04-12 Issue:15 Volume:131 Page:1720-1729
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Manček-Keber Mateja¹,Lainšček Duško¹,Benčina Mojca¹²,Chen Jiaji G.³⁴^ORCID,Romih Rok⁵,Hunter Zachary R.³⁴^ORCID,Treon Steven P.³⁴^ORCID,Jerala Roman¹²^ORCID

Affiliation:

1. Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia;

2. EN-FIST Centre of Excellence, Ljubljana, Slovenia;

3. Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA;

4. Department of Medicine, Harvard Medical School, Boston, MA; and

5. Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Abstract

Key Points MyD88L265P is present in the EVs secreted by WM cancer cells and triggers signaling in the recipient cells. MyD88-containing EVs shape the proinflammatory microenvironment in the bone marrow.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/15/1720/1406055/blood805499.pdf

Reference50 articles.

1. An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4;Motshwene;J Biol Chem,2009

2. Assembly and localization of Toll-like receptor signalling complexes;Gay;Nat Rev Immunol,2014

3. TLR signaling;Kawai;Cell Death Differ,2006

4. Pyogenic bacterial infections in humans with MyD88 deficiency;von Bernuth;Science,2008

5. Oncogenically active MYD88 mutations in human lymphoma;Ngo;Nature,2011

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Proteomic profile of tissue-derived extracellular vesicles from benign odontogenic lesions;Journal of Stomatology, Oral and Maxillofacial Surgery;2024-09

2. Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo;Cancer Gene Therapy;2024-06-25

3. Caspase‐3 and gasdermin E mediate macrophage pyroptosis in periodontitis;Journal of Periodontal Research;2023-10-26

4. Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy;Journal of Neurology, Neurosurgery & Psychiatry;2023-10-25

5. The Role of Extracellular Vesicles in the Pathogenesis of Hematological Malignancies: Interaction with Tumor Microenvironment; a Potential Biomarker and Targeted Therapy;Biomolecules;2023-05-27