NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages-Reference-Cited by-同舟云学术

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages

Published:2018-05-24 Issue:21 Volume:131 Page:2367-2378
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bagaitkar Juhi¹²^ORCID,Huang Jing¹,Zeng Melody Yue³⁴⁵⁶^ORCID,Pech Nancy K.¹,Monlish Darlene A.¹,Perez-Zapata Lizet J.¹,Miralda Irina²,Schuettpelz Laura G.¹,Dinauer Mary C.¹³⁴⁷

Affiliation:

1. Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO;

2. Department of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY;

3. Department of Pediatrics and

4. Department of Microbiology and Immunology, School of Medicine, Indiana University, Indianapolis, IN;

5. Department of Pathology and

6. Comprehensive Cancer Center, Medical School, University of Michigan, Ann Arbor, MI; and

7. Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO

Abstract

Key Points Efferocytosis of ACs by inflammatory macrophages activates NADPH oxidase in a CD11b-TLR2/4-MyD88–dependent manner. ROS generated positively regulate acidification and proteolysis in efferosomes, and limit cross-presentation of AC-associated antigens.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/21/2367/1468162/blood809004.pdf

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