Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans-Reference-Cited by-同舟云学术

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans

Published:2018-06-14 Issue:24 Volume:131 Page:2605-2616
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Busygina Kristina¹,Jamasbi Janina¹,Seiler Till²,Deckmyn Hans³,Weber Christian¹⁴⁵,Brandl Richard⁶,Lorenz Reinhard¹,Siess Wolfgang¹⁴^ORCID

Affiliation:

1. Institute for the Prevention of Cardiovascular Diseases and

2. Medical Clinic III, Ludwig-Maximilians University, Munich, Germany;

3. Laboratory for Thrombosis Research, Katholic University (KU) Leuven Campus Kortrijk, Kortrijk, Belgium;

4. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany;

5. Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; and

6. St. Mary’s Square Institute for Vascular Surgery and Phlebology, Munich, Germany

Abstract

Key Points Btk inhibitors specifically block platelet thrombus formation on atherosclerotic plaque but spare physiologic hemostasis. Irreversible Btk inactivation in platelets incapable of enzyme resynthesis allows low intermittent drug dosing for antiatherothrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/24/2605/1469205/blood808808.pdf

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5. Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo;Schulz;Basic Res Cardiol,2008

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