Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors

Author:

Kawano Yohei123,Petkau Georg12,Stehle Christina1,Durek Pawel1,Heinz Gitta Anne1,Tanimoto Kousuke4,Karasuyama Hajime3,Mashreghi Mir-Farzin1,Romagnani Chiara1,Melchers Fritz12

Affiliation:

1. Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany;

2. Max-Planck Institute for Infection Biology, Berlin, Germany; and

3. Department of Immune Regulation, Graduate School of Medical and Dental Sciences, and

4. Genome Laboratory, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Abstract

Key Points We have established a novel culture system for long-term proliferating murine lymphoid progenitors without any genetic manipulation. The cultured lymphoid progenitors can differentiate to lymphoid and myeloid lineages in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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