Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation-Reference-Cited by-同舟云学术

Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation

Published:2018-05-03 Issue:18 Volume:131 Page:2036-2046
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Viganò Elena¹²,Gunawardana Jay¹²,Mottok Anja¹²³⁴,Van Tol Tessa¹,Mak Katina¹,Chan Fong Chun¹²,Chong Lauren¹,Chavez Elizabeth¹,Woolcock Bruce¹,Takata Katsuyoshi¹,Twa David¹²,Shulha Hennady P.¹,Telenius Adèle¹,Kutovaya Olga¹²,Hung Stacy S.¹,Healy Shannon¹²,Ben-Neriah Susana¹,Leroy Karen⁵,Gaulard Philippe⁶⁷⁸,Diepstra Arjan⁹,Kridel Robert¹²,Savage Kerry J.¹,Rimsza Lisa¹⁰,Gascoyne Randy¹²,Steidl Christian¹²

Affiliation:

1. Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada;

2. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada;

3. Institute of Pathology, University of Würzburg, Würzburg, Germany;

4. Comprehensive Cancer Centre Mainfranken, Würzburg, Germany;

5. University Paris Descartes, Paris, France;

6. Département de Pathologie–Service d'Hématologie–Plateforme de Ressources Biologiques, Groupe Hospitalier Henri-Mondor, Assistance Publique–Hôpitaux de Paris, Créteil, France;

7. INSERM U955, Créteil, France;

8. Université Paris Est, Créteil, France;

9. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; and

10. Department of Pathology, University of Arizona, Tucson, AZ

Abstract

Key Points Somatic IL4R mutations were identified in 24% of primary PMBCL cases (n = 62) and in 100% of PMBCL-derived cell lines. IL4R mutations lead to hyperphosphorylation of STAT proteins activating downstream immunoregulatory genes (CD23, CCL17).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/18/2036/1406089/blood808907.pdf

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