Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals-Reference-Cited by-同舟云学术

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals

Published:2018-02-01 Issue:5 Volume:131 Page:546-557
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tucci Felicia A.¹^ORCID,Kitanovski Simo²,Johansson Patricia¹³,Klein-Hitpass Ludger¹,Kahraman Alisan⁴,Dürig Jan³,Hoffmann Daniel²⁵,Küppers Ralf¹⁵^ORCID

Affiliation:

1. Institute of Cell Biology (Cancer Research), Medical Faculty,

2. Bioinformatics and Computational Biophysics, Faculty of Biology, and

3. Department of Hematology, Medical Faculty, University of Duisburg-Essen, Essen, Germany;

4. Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany; and

5. Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany

Abstract

Key PointsChronic HCV infection leads to extensive BCR immunoglobulin gene repertoire alterations with pathological features even in absence of MC. Many large B-cell clones are consistently found, mainly among IgM+ memory B cells, showing a massive influence of HCV on this compartment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/5/546/1466155/blood805762.pdf

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