Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma-Reference-Cited by-同舟云学术

Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma

Published:2018-02-15 Issue:7 Volume:131 Page:771-781
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kohnken Rebecca¹²,Wen Jing²,Mundy-Bosse Bethany²³,McConnell Kathleen²,Keiter Ashleigh²,Grinshpun Leah²,Hartlage Alex²,Yano Max²,McNeil Betina²,Chakravarti Nitin⁴,William Basem²³,Bradner James E.⁵,Caligiuri Michael A.²³,Porcu Pierluigi²³,Mishra Anjali²⁶

Affiliation:

1. Department of Veterinary Biosciences,

2. Comprehensive Cancer Center,

3. Division of Hematology, Department of Internal Medicine, and

4. Nationwide Children’s Hospital, The Ohio State University, Columbus, OH;

5. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and

6. Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, OH

Abstract

Key Points CTCL patients have decreased miR-29b levels and increased BRD4 binding occupancy at promoter regions of tumor-associated genes. Therapeutic targeting of miR-29b and BRD4 in CTCL mice results in significantly decreased disease severity and progression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/7/771/1406801/blood805663.pdf

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3. Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2;Ungewickell;Nat Genet,2015

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