Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency

Author:

Fox Thomas A.12,Chakraverty Ronjon234,Burns Siobhan123,Carpenter Benjamin25,Thomson Kirsty24,Lowe David16,Fielding Adele234,Peggs Karl24,Kottaridis Panagiotis23,Uttenthal Benjamin7,Bigley Venetia8,Buckland Matthew16,Grandage Victoria5,Denovan Shari235,Grace Sarah235,Dahlstrom Julia25,Workman Sarita6,Symes Andrew6,Mackinnon Stephen234,Hough Rachael5,Morris Emma126ORCID

Affiliation:

1. Institute of Immunity and Transplantation, University College London (UCL), London, United Kingdom;

2. Bone Marrow Transplant (BMT) Programme, UCL Hospital National Health Service Foundation Trust (NHS FT), London, United Kingdom;

3. Department of Haematology, Royal Free London NHS FT, London, United Kingdom;

4. Department of Haematology, Cancer Institute, UCL, London, United Kingdom;

5. Teenage and Young Adult BMT Programme, UCL Hospital NHS FT, London, United Kingdom;

6. Department of Immunology, Royal Free London NHS FT, London, United Kingdom;

7. Department of Haematology, Addenbrookes’ Hospital, Cambridge, United Kingdom; and

8. Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom

Abstract

Key Points Allo-HSCT with RIC is safe and effective in younger adults with severe PID. Referral triggers should include severe infections, autoimmunity, malignancy, and disease progression despite conservative management.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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