Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection-Reference-Cited by-同舟云学术

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Published:2013-07-18 Issue:3 Volume:122 Page:348-356
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schmitt Thomas M.¹,Aggen David H.²,Stromnes Ingunn M.¹,Dossett Michelle L.³,Richman Sarah A.⁴,Kranz David M.²,Greenberg Philip D.¹

Affiliation:

1. Fred Hutchinson Cancer Research Center and the Departments of Immunology and Medicine, University of Washington, Seattle, WA;

2. Department of Biochemistry, University of Illinois, Urbana, IL;

3. Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA; and

4. Children’s Hospital of New York, Columbia University Medical Center, New York, NY

Abstract

Key Points High-affinity tumor/self antigen-specific TCRs that surpass the threshold for normal thymic selection can be safe for TCR gene therapy. T cells that express endogenous TCRs that are self-reactive can survive in the periphery with diminished TCR expression levels.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/3/348/1371980/348.pdf

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4. Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions.;Robbins;J Immunol,2008

5. Directed evolution of human T-cell receptors with picomolar affinities by phage display.;Li;Nat Biotechnol,2005

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