Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice-Reference-Cited by-同舟云学术

Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice

Published:2014-01-30 Issue:5 Volume:123 Page:659-668
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gentle Ian E.¹,Moelter Isabel²³,Lechler Nadja²³,Bambach Sarah²³,Vucikuja Smiljka²,Häcker Georg¹,Aichele Peter²

Affiliation:

1. Institute of Microbiology and Hygiene,

2. Institute of Immunology, Department of Medical Microbiology and Hygiene, and

3. Faculty of Biology, University of Freiburg, Freiburg, Germany

Abstract

Key Points IAPs are required for survival and expansion of activated T cells. IAP antagonists sensitize to tumor necrosis factor (TNF)-induced cell death of activated T cells during viral infection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/5/659/1378609/659.pdf

Reference43 articles.

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3. The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.;Eckelman;J Biol Chem,2006

4. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.;Gyrd-Hansen;Nat Rev Cancer,2010

5. IAPs, RINGs and ubiquitylation.;Vaux;Nat Rev Mol Cell Biol,2005

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