Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors-Reference-Cited by-同舟云学术

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

Published:2013-05-02 Issue:18 Volume:121 Page:3675-3681
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Altman Jessica K.¹²,Szilard Amy¹,Konicek Bruce W.³,Iversen Philip W.³,Kroczynska Barbara¹,Glaser Heather¹,Sassano Antonella¹,Vakana Eliza¹,Graff Jeremy R.³,Platanias Leonidas C.¹²

Affiliation:

1. Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

2. Division of Hematology-Oncology, Department of Medicine, Jesse Brown VA Medical Center, Chicago, IL; and

3. Lilly Research Laboratories, Cancer Biology and Patient Tailoring, Eli Lilly and Company, Indianapolis, IN

Abstract

Key Points The Mnk inhibitor cercosporamide suppresses human leukemic progenitors and exhibits antileukemic effects in a xenograft mouse model. Cercosporamide enhances the antileukemic effects of cytarabine in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3675/1363410/3675.pdf

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