Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice-Reference-Cited by-同舟云学术

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Published:2013-08-01 Issue:5 Volume:122 Page:781-790
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Doyle Alfred D.¹,Jacobsen Elizabeth A.¹,Ochkur Sergei I.¹,McGarry Michael P.¹,Shim Kevin G.¹,Nguyen David T. C.²,Protheroe Cheryl¹,Colbert Dana²,Kloeber Jake¹,Neely Joseph²,Shim Kelly P.¹,Dyer Kimberly D.³,Rosenberg Helene F.³,Lee James J.¹,Lee Nancy A.²

Affiliation:

1. Division of Pulmonary Medicine,

2. Division of Hematology/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ; and

3. Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

Abstract

Key Points The loss of the two most abundant eosinophil granule proteins disrupts the production of blood eosinophils from marrow progenitors. Knockout animals deficient for both MBP-1 and EPX represent a novel strain of mice with a specific and congenital loss of eosinophils.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/781/1373769/781.pdf

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4. The identification and cloning of a murine major basic protein gene expressed in eosinophils.;Larson;J Immunol,1995

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