Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia-Reference-Cited by-同舟云学术

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

Published:2013-07-04 Issue:1 Volume:122 Page:100-108
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Krönke Jan¹,Bullinger Lars¹,Teleanu Veronica¹,Tschürtz Florian¹,Gaidzik Verena I.¹,Kühn Michael W. M.¹,Rücker Frank G.¹,Holzmann Karlheinz²,Paschka Peter¹,Kapp-Schwörer Silke¹,Späth Daniela¹,Kindler Thomas³,Schittenhelm Marcus⁴,Krauter Jürgen⁵,Ganser Arnold⁵,Göhring Gudrun⁶,Schlegelberger Brigitte⁶,Schlenk Richard F.¹,Döhner Hartmut¹,Döhner Konstanze¹

Affiliation:

1. Department of Internal Medicine III, and

2. Interdisciplinary Center for Clinical Research, Genomics Core Facility, University of Ulm, Ulm, Germany;

3. University Medical Center, Johannes Gutenberg University, Mainz, Germany;

4. Department of Hematology/Oncology, Eberhard Karls University, Tübingen, Germany; and

5. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, and

6. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

Abstract

Key Points Relapsed AML with NPM1 mutation is genetically related to the primary leukemia and characterized by an increase in high-risk aberrations. DNMT3A mutations show the highest stability and thus may precede NPM1 mutations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/1/100/1368886/100.pdf

Reference44 articles.

1. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.;Falini;N Engl J Med,2005

2. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias.;Fitzgibbon;Cancer Res,2005

3. Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis.;Bullinger;Leukemia,2010

4. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.;Figueroa;Cancer Cell,2010

5. Recurring mutations found by sequencing an acute myeloid leukemia genome.;Mardis;N Engl J Med,2009

Cited by 235 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Common Driver Mutations in AML: Biological Impact, Clinical Considerations, and Treatment Strategies;Cells;2024-08-21

2. Insight into the mechanism of AML del(9q) progression: hnRNP K targets the myeloid master regulators CEBPA (C/EBPα) and SPI1 (PU.1);Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms;2024-03

3. The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies;Frontiers in Oncology;2024-02-19

4. Hematopoietic Cell Transplantation in Adult With Acute Myeloid Leukemia;Manual of Hematopoietic Cell Transplantation and Cellular Therapies;2024

5. Myeloid neoplasm occurrence during stable molecular remission of NPM1-mutated AML: are we facing secondary disease or AML relapse?;Blood Cancer Journal;2023-12-21