Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies-Reference-Cited by-同舟云学术

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

Published:2013-10-17 Issue:16 Volume:122 Page:2837-2847
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nayar Utthara¹,Lu Pin¹,Goldstein Rebecca L.²,Vider Jelena³,Ballon Gianna¹,Rodina Anna⁴,Taldone Tony⁴,Erdjument-Bromage Hediye⁵,Chomet Max¹,Blasberg Ronald³⁶,Melnick Ari²,Cerchietti Leandro²,Chiosis Gabriela⁴,Wang Y. Lynn¹,Cesarman Ethel¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, and

2. Department of Medicine, Weill Cornell Medical College, New York, NY; and

3. Department of Neurology,

4. Department of Molecular Pharmacology and Chemistry,

5. Molecular Biology, and

6. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY

Abstract

Key Points Hsp90 oncoproteome analysis identifies relevant pathways in KSHV-associated primary effusion lymphoma that can inform novel combinatorial therapies. The Hsp90 inhibitor PU-H71 affects chaperoning of KSHV viral proteins, blocking latent and lytic viral functions.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/16/2837/1369677/2837.pdf

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