Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia-Reference-Cited by-同舟云学术

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

Published:2013-10-10 Issue:15 Volume:122 Page:2694-2703
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Goldberg Liat¹²,Tijssen Marloes R.³,Birger Yehudit¹,Hannah Rebecca L.³,Kinston Sarah J.³,Schütte Judith³,Beck Dominik⁴,Knezevic Kathy⁴,Schiby Ginette⁵,Jacob-Hirsch Jasmine¹,Biran Anat⁶,Kloog Yoel⁶,Marcucci Guido⁷,Bloomfield Clara D.⁷,Aplan Peter D.⁸,Pimanda John E.⁴,Göttgens Berthold³,Izraeli Shai¹²

Affiliation:

1. Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;

2. Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel;

3. Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom;

4. Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia;

5. Department of Pathology, Sheba Medical Center and Sackler Faculty of Medicine, and

6. Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel;

7. Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and

8. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points ERG overexpression in transgenic mice induces a transcriptional leukemia stem cell program characteristic of human AML. PIM1 and RAS are relevant ERG therapeutic targets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/15/2694/1369985/2694.pdf

Reference55 articles.

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4. EWS-erg and EWS-Fli1 fusion transcripts in Ewing’s sarcoma and primitive neuroectodermal tumors with variant translocations.;Giovannini;J Clin Invest,1994

5. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.;Kong;Blood,1997

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