Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia-Reference-Cited by-同舟云学术

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia

Published:2013-09-05 Issue:10 Volume:122 Page:1761-1769
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Opatz Sabrina¹²³,Polzer Harald¹⁴,Herold Tobias¹⁴,Konstandin Nikola P.¹,Ksienzyk Bianka¹,Zellmeier Evelyn¹,Vosberg Sebastian¹⁴,Graf Alexander⁵,Krebs Stefan⁵,Blum Helmut⁵,Hopfner Karl-Peter⁶,Kakadia Purvi M.¹⁷,Schneider Stephanie¹,Dufour Annika¹,Braess Jan⁸,Sauerland Maria Cristina⁹,Berdel Wolfgang E.¹⁰,Büchner Thomas¹⁰,Woermann Bernhard J.¹¹,Hiddemann Wolfgang¹²³⁴,Spiekermann Karsten¹²³⁴,Bohlander Stefan K.⁴⁷,Greif Philipp A.¹²³⁴

Affiliation:

1. Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany;

2. German Cancer Consortium (DKTK), Heidelberg, Germany;

3. German Cancer Research Centre (DKFZ), Heidelberg, Germany;

4. Clinical Cooperative Group Leukemia, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany;

5. Laboratory for Functional Genome Analysis, and

6. Department of Biochemistry at the Gene Center, Munich, Germany;

7. Center for Human Genetics, Philipps University Marburg, Marburg, Germany;

8. Oncology and Hematology, St. John of God Hospital, Regensburg, Germany;

9. Institute of Biostatistics and Clinical Research, and

10. Department of Medicine A, Hematology, Oncology and Pneumology, Universität Münster, Münster, Germany; and

11. German Society of Hematology and Oncology, Berlin, Germany

Abstract

Key Points FLT3 N676K mutations without concurrent internal tandem duplication (ITD) are associated with core-binding factor leukemia. N676K activates FLT3 and downstream signaling pathways.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/10/1761/1367832/1761.pdf

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