Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients-Reference-Cited by-同舟云学术

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients

Published:2013-07-18 Issue:3 Volume:122 Page:434-442
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Galarneau Geneviève¹²,Coady Sean³,Garrett Melanie E.⁴,Jeffries Neal³,Puggal Mona³,Paltoo Dina³,Soldano Karen⁴,Guasch Antonio⁵,Ashley-Koch Allison E.⁴,Telen Marilyn J.⁶,Kutlar Abdullah⁷,Lettre Guillaume¹²,Papanicolaou George J.³

Affiliation:

1. Montreal Heart Institute, Montreal, Quebec, Canada;

2. Université de Montréal, Montreal, Quebec, Canada;

3. National Heart, Lung, and Blood Institute, Division of Cardiovascular Sciences, Bethesda, MD;

4. Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC;

5. Emory University, Atlanta, GA;

6. Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC; and

7. Department of Medicine, Sickle Cell Center, Medical College of Georgia, Augusta, GA

Abstract

Key Points Using genome-wide association study, we found the first replicated genetic association with acute chest syndrome in sickle cell disease patients. The locus identified includes COMMD7, a gene highly expressed in the lung that interacts with NFκB to control inflammatory responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/3/434/1372245/434.pdf

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