PROGNOSIS IN THE NEUROLOGIC MANIFESTATIONS OF PERNICIOUS ANEMIA

Author:

RUNDLES R. WAYNE1

Affiliation:

1. Department of Medicine, Duke University School of Medicine. This study was begun at the Simpson Memorial Institute, University of Michigan. The crystalline vitamin products were furnished by the Upjohn Company.

Abstract

Abstract Four types of disturbed neurologic function occur in pernicious anemia: (1) cerebral, (2) olfactory, (3) peripheral nerve and posterior columns of the spinal cord, and (4) lateral columns of the spinal cord. The neurologic prognosis depends upon the specific type of disability present, its severity, duration, and the adequacy of treatment. With intensive use of highly potent liver extracts intramuscularly the prognosis is far better than generally recognized. Serious neurologic residuals can be avoided if the diagnosis is made reasonably early.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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