Affiliation:
1. Blood Research Laboratory, a unit of the Ziskind Laboratories, New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Mass.
Abstract
Abstract
1. Three patients with lymphosarcomatosis and two with disseminated Hodgkin’s disease were treated with massive doses (super-dosage) of nitrogen mustard (over 1.0 mg./Kg.) given intravenously, followed by the intravenous infusion of autologous bone marrow.
2. Two of the five patients succumbed to infection. The remaining three patients recovered within one month and experienced brief remissions.
3. It is suggested that this form of therapy merits further trial. Thus, it may be considered for use earlier in the course of the disease when there is a smaller total amount of tumor tissue, and thus a greater possibility for its complete eradication. Its use in other neoplastic disorders, as following operative procedures disclosing malignancy, is suggested.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
98 articles.
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