Determination of Lymphocyte Turnover by Continuous Infusion of H3 Thymidine-Reference-Cited by-同舟云学术

Determination of Lymphocyte Turnover by Continuous Infusion of H3 Thymidine

Published:1962-02-01 Issue:2 Volume:19 Page:236-242
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

LITTLE J. R.¹²,BRECHER GEORGE¹³,BRADLEY T. R.¹⁴,ROSE S.¹⁵

Affiliation:

1. Laboratory of Experimental Pathology, National Institute of Arthritis and Metabolic Diseases, and the Department of Clinical Pathology, Clinical Center, National Institutes of Health, Bethesda, Md.

2. Clinical Pathology Department, Clinical Center, Bethesda, Md.

3. Hematology Service, Clinical Pathology Department, Clinical Center, Bethesda, Md.

4. National Cancer Institute, on leave from Department of Physiology, University of Melbourne, Australia.

5. National Institute of Arthritis and Metabolic Diseases, on leave from Department of Physiology, University of Melbourne, Australia.

Abstract

Abstract The use of an osmotic pump for continuous infusion of H3 thymidine in rats is described. Estimates of turnover times of cells in the peripheral blood are 4 days for granulocytes, 60 days for large lymphocytes and in excess of 100 days for small lymphocytes. These turnover times include initial delay in release or maturation after the last mitosis in the marrow or nodes, and any time spent outside the circulation prior to final disappearance of a given cell from the peripheral blood. The data exclude reutilization as an explanation for the observed longevity of lymphocytes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/19/2/236/570415/236.pdf

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