Hemorrhagic Disease with Circulating Inhibitors of Blood Clotting: Anti-AHF and Anti-PTC in Eight Cases

Author:

LEWIS JESSICA H.1,FERGUSON JOHN H.1,ARENDS TULIO1

Affiliation:

1. Department of Physiology, University of North Carolina, Chapel Hill, and the Department of Medicine, Duke University.

Abstract

Abstract In eight patients suffering from severe hemorrhagic disease it was possible to demonstrate the presence of circulating inhibitors, not heparin-like in nature. Anti-PTC was identified in two PTC deficients, anti-AHF in 5 hemophilics and both, primarily anti-AHF, in one idiopathic case. Possible etiologic factors inducing the appearance of such inhibitors included repeated transfusions of whole blood and plasma in all and a previous pregnancy in the idiopathic case. Two patients showed increases of gamma-globulin and presence of inhibitor in 25-33 per cent ammonium sulfate plasma fractions. Cortisone therapy was ineffective in two cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 53 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3