Affiliation:
1. Departments of Pathology and Haematology, School of Tropical Medicine, Calcutta, India.
Abstract
Abstract
Histologic and histochemical study of the foam cell in the spleen in thalassemia has shown that the foamy appearance is due to the accumulation of an acidic mucopolysaccharide of the chondroitin sulfuric acid type in the cytoplasm of this histiocytic cell. This polysaccharide shows intense red coloration with the periodic acid Schiff reaction, which is thus of great value in demonstrating the foam cell in tissue sections. The possible sources of this mucopolysaccharide have been discussed.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
14 articles.
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1. Secondary Sea-Blue Histiocytosis in a Patient with Transfusion Dependent HbE-Beta Thalassaemia and Osteosarcoma;Indian Journal of Hematology and Blood Transfusion;2015-08-29
2. Spleen;Rosai and Ackerman's Surgical Pathology;2011
3. Transfusion Hemochromatosis in Cooley's Anemia*;Annals of the New York Academy of Sciences;2006-12-16
4. LESIONS OF THE LIVER IN HEREDITARY METABOLIC DISEASES;Annals of the New York Academy of Sciences;2006-12-15
5. The Pathology of the Spleen;The Complete Spleen;2002