Evaluation of a New Chemotherapeutic Agent in Patients with "Advanced Refractory" Acute Leukemia. Studies of 6-Azauracil-Reference-Cited by-同舟云学术

Evaluation of a New Chemotherapeutic Agent in Patients with "Advanced Refractory" Acute Leukemia. Studies of 6-Azauracil

Published:1960-09-01 Issue:3 Volume:16 Page:1268-1278
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

FREIREICH EMIL J.¹,FREI EMIL¹,HOLLAND JAMES F.²,PINKEL DONALD²,SELAWRY OLEG²,ROTHBERG HARVEY³,HAURANI FARID⁴,TAYLOR ROBERT¹,GEHAN EDMUND A.¹

Affiliation:

1. National Cancer institute, Bethesda. Md.

2. Roswell Park Memorial Institute, Buffalo. N. Y.

3. Walter Reed Army Hosptial, Washington, D. C.

4. Jefferson Medical College, Philadelphia, Pa.

Abstract

Abstract 6-Azauracil was studied in patients with "advanced" acute leukemia, refractory to standard chemotherapy. Under the conditions of the study this compound was found to have no significant antileukemic activity. As a result, these data have defined the natural history of this phase of acute leukemia. A significant proportion (30 per cent) of these patients showed objective hematologic improvement even in the absence of effective specific therapy, which might be ascribed to a prospective new agent. The median survival from the onset of the study of this group of patients was two months, and survival patterns for adults and children were similar.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/16/3/1268/569513/1268.pdf

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