The Chemical and Genetic Relationships Between Hemoglobins S and GSan Jose-Reference-Cited by-同舟云学术

The Chemical and Genetic Relationships Between Hemoglobins S and GSan Jose

Published:1962-05-01 Issue:5 Volume:19 Page:573-586
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

HILL ROBERT L.¹²,SWENSON ROBERT T.¹³,SCHWARTZ HERBERT C.¹⁴

Affiliation:

1. Laboratory for the Study of Hereditary and Metabolic Disorders and the Departments of Biological Chemistry and Medicine, University of Utah College of Medicine, Salt Lake City, Utah, and the Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif.

2. Present address: Associate Professor of of Biochemistry, Duke University School of Medicine, Durham, N.C.

3. American Cancer Society, 1959-1961; Fellow in Biochemistry, University of Utah College of Medicine, Salt Lake City, Utah.

4. Present address: Assistant Professor of Pediatrics, Stanford University Medical Center, Palo Alto, Calif.

Abstract

Abstract 1. Comparison of the structures of the S-carboxymethylglobin derivatives of hemoglobins A, S and G shows that the only differences in the structure of these proteins resides in the βTpI peptides. 2. When structural methods are used to determine the types of hemoglobin in individuals from a family that possesses genes for hemoglobins A, S and G, it is possible to show that hemoglobins S and G are not inherited by nonallelic genes. 3. Previous difficulties in judging the hemoglobin types in this family by electrophoretic methods were caused by electrophoretically abnormal minor hemoglobin components. 4. The minor hemoglobin components which are observed in this family appear to arise by denaturation of the major hemoglobin component.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/19/5/573/570592/573.pdf

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