Studies of Coagulation and Fibrinolysis by New Technic of Continuous Recording

Abstract

Abstract 1. The Hartert instrument is a useful tool for recording continuously changes in a physical property of the clot during its formation and dissolution. 2. Alterations in fibrinogen content, platelets, and plasma clotting factors influence the pattern of the coagulogram. These patterns do not necessarily parallel the results of classical clotting time studies based on observation of the time necessary to form a visible clot. Clearly visible clots may not be sufficiently firm to be recorded by the coagulograph. 3. Coagulograph studies require careful handling of blood specimens to avoid artefacts of extrinsic origin. 4. The lysis of clots by different enzymes follows significantly different patterns which are not detectable by the standard methods for observing the dissolution of a clot.