The Morphologic Responses of the Lymphoid System to Homografts. II. The Effects of Antimetabolites-Reference-Cited by-同舟云学术

The Morphologic Responses of the Lymphoid System to Homografts. II. The Effects of Antimetabolites

Published:1962-03-01 Issue:3 Volume:19 Page:334-348
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

ANDRÉ JANINE A.¹²,SCHWARTZ ROBERT S.¹³,MITUS W. J.¹³,DAMESHEK WILLIAM¹⁴

Affiliation:

1. Blood Research Laboratory, Pratt Clinic-New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Mass.

2. Blood Research Laboratory, New England Center Hospital; Assistant in Medicine, Tufts University Scrool of Medicine, Boston, Mass. Formerly Attacheé de Recherche au Centre Nationale de la Recherche Scientifique, Service du Prof esseur Gadrat, Pourpon, Toulouse, France.

3. Blood Research Laboratory, New England Center Hospital, and Assistant Professor of Medicine, Tufts University School of Medicine, Boston, Mass.

4. Blood Research Laboratory, New England Center Hospital, and Professor of Medicine, Tufts University School of Medicine, Boston, Mass.

Abstract

Abstract The effects of 6-mercaptopurine and thioguanine on the morphologic responses of lymph nodes and spleen were studied in the rabbit. The main effect of these drugs was to inhibit the proliferation of hemocytoblasts, cells considered to be immunologically competent. Homograft rejection did not occur as long as these cells were suppressed. Rabbits which rejected their grafts in spite of continued 6-mercaptopurine treatment developed large numbers of hemocytoblasts in their lymphoid apparatus. These cells were thought to be drug resistant and analogous to resistant leukemic cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/19/3/334/570389/334.pdf

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