Effect of Thymus Enclosed in Millipore Diffusion Envelopes on Thymectomized Hamsters

Author:

WONG F. M.1,TAUB R. N.1,SHERMAN J. D.1,DAMESHEK W.1

Affiliation:

1. Blood Research Laboratory, Pratt Clinic-New England Medical Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Abstract

Abstract Neonatally thymectomized hamsters implanted with diffusion envelopes containing thymus showed partial prevention of the effects of thymectomy. A normal humoral antibody response was maintained in these animals, although a significant lymphocytopenia remained. This suggests that the thymus participates in immunogenesis by a humoral mechanism and possibly by a cellular mechanism as well, which was blocked by the diffusion envelope. Thymectomized hamsters implanted with diffusion envelopes containing adult spleen, bone marrow or kidney were still impaired in their ability to produce humoral antibody, although these tissues appeared to enhance antibody production. The thymus humoral factor appeared to be specific to the thymus. Reimplanted diffusion envelopes, containing large thymic cells resembling epithelial-reticular cells, were used to show that these cells produced the thymus humoral factor.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 21 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Hormonal coordination of the immune response;Reviews of Physiology, Biochemistry and Pharmacology;1982

2. T-LYMPHOCYTE MATURATION: CELL SURFACE MARKERS AND IMMUNE FUNCTION INDUCED BY T-LYMPHOCYTE CELL-FREE PRODUCTS AND THYMOSIN POLYPEPTIDES;Annals of the New York Academy of Sciences;1979-12

3. IN VITRO AND IN VIVO STUDIES WITH THYMOSIN IN CANCER PATIENTS;Annals of the New York Academy of Sciences;1976-09

4. Bursal dissections and gill pouch hormones;Nature;1976-02-05

5. Thymic hormones and the immune response.;Physiological Reviews;1974-04

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